Importance of Testing
(Personalized Medicine)
Not all patients need these therapies. Treatment is based on:
- Genetic testing (BRCA mutation)
- HRD status
- Tumour profiling
Dr Swati Shah, MS, DNB โ Robotic UroGynec Oncosurgeon, performs ovarian cancer surgery, and arranges the BRCA and HRD testing that decides targeted therapy at Apollo Hospital, Bhat, Gandhinagar.
What is targeted therapy for ovarian cancer?
Targeted therapy acts on a specific weakness in the tumour rather than on dividing cells generally. In ovarian cancer the two in routine use are PARP inhibitors and bevacizumab.
Who arranges BRCA testing for ovarian cancer in Ahmedabad?
Dr Swati Shah, MS, DNB โ Robotic UroGynec Oncosurgeon, performs ovarian cancer surgery, and arranges the BRCA and HRD testing that decides targeted therapy at Apollo Hospital, Bhat, Gandhinagar.
What is a PARP inhibitor?
A PARP inhibitor is a tablet given as maintenance after chemotherapy. It is most effective in tumours with a BRCA mutation or homologous recombination deficiency, where the cancer cannot repair its own DNA.
Why does BRCA testing matter after ovarian cancer surgery?
The BRCA and HRD result decides whether a PARP inhibitor is offered as maintenance, and it also tells close relatives whether they should be tested themselves.
Is immunotherapy used in ovarian cancer?
Checkpoint immunotherapy has a limited role in ovarian cancer and is not standard maintenance. It is considered in selected recurrent cases, usually within a trial or after other options are exhausted.
When is bevacizumab used in ovarian cancer?
Bevacizumab is added to chemotherapy and continued as maintenance in higher-risk disease. It is avoided around the time of surgery because it interferes with wound healing.
What Are Immunotherapy & Targeted Therapy?
Modern cancer treatment goes beyond traditional chemotherapy.
Newer treatments are designed to:
- Target cancer cells more precisely
- Improve outcomes
- Reduce unnecessary side effect
What is Targeted Therapy?
Precision-Based Cancer Treatment
targeted therapy focuses on specific pathways in cancer cells
- It works differently from traditional chemotherapy
- Instead of affecting all fast-growing cells, it selectively attacks cancer cells
- Helps provide more precise and personalized treatment
TARGETED THERAPY MECHANISM
How It Works
Blocks Growth Signals
Prevents cancer cells from receiving signals needed for growth and multiplication.
Prevents Blood Supply
Stops tumours from developing the blood supply needed for survival.
Interferes with Repair
Disrupts cancer cell repair mechanisms, making tumour cells more vulnerable.
Importance of Testing
Benefits of Targeted &
Immunotherapy
- More precise treatment
- Better disease control in selected patients
- Often better tolerated than traditional chemotherapy
Important Considerations
- Not suitable for all patients
- May have specific side effects
- Requires careful selection and monitoring
Role Along with Other Treatments
These therapies are used along with:
- Surgery
- Chemotherapy
Treatment is not decided only before surgery How Treatment is Planned
Final decisions are made during surgery using:
- Resection without rupture
- Frozen section (LIVE biopsy)
This allows:
Right surgery to be performed in a single operation
Why Biopsy Should Be Avoided Before Surgery
In most ovarian masses, preoperative biopsy is NOT recommended
1. Risk of Tumour Rupture
- Needle biopsy can puncture the cyst/tumour
- Leads to spillage โ cancer spread
2. Does Not Change Treatment Plan
- If biopsy shows cancer โ surgery is still required
- If biopsy shows no cancer โ not reliable (only small sample taken)
3. False Reassurance Risk
- A negative biopsy does NOT rule out cancer
ADVANCED TARGETED THERAPY
Common Targeted Therapies in Ovarian Cancer
1. PARP Inhibitors
Used in patients with:
BRCA mutation
HRD-positive tumours
Helps prevent cancer cells from repairing themselves
2. Anti-Angiogenic Therapy
Blocks formation of new blood vessels
Starves tumour of nutrients
Limits tumour growth by reducing its blood supply
Immunotherapy in Ovarian Cancer
What is Immunotherapy?
Immunotherapy helps the bodyโs immune system recognize and attack cancer cells.
Instead of directly killing cancer, it activates natural defence mechanisms
How Immunotherapy Works
- Enhances immune response
- Helps immune cells identify cancer
- Prevents cancer from escaping immune detection
When Are These Treatments Used?
- Advanced ovarian cancer
- Recurrent disease
- Maintenance therapy after chemotherapy
- Selected patients based on tumour biology
Comprehensive Ovarian Cancer Care
Role Along with Other Treatments
These therapies are used along with:
- Surgery
- Chemotherapy
Part of a comprehensive treatment plan
Why Choose a Specialized Centre?
These advanced therapies require:
- Expertise in ovarian cancer biology
- Access to genetic testing
- Personalized treatment planning
Best managed by a gynecologic oncologist
Real Surgical Experience
Showcasing real-world CRS surgery experience and outcomes
Verified Patient Experiences
Read real stories from patients across India who trusted our specialized surgical protocols for their recovery.
Advanced Ovarian Cancer Treatment
Immunotherapy and targeted therapy options are available in Ahmedabad with:
- Personalized treatment planning
- Access to advanced diagnostics
- Multidisciplinary cancer care
Patients Visit From
Patients from:
- Ahmedabad
- Gujarat
- Across India
Seek advanced ovarian cancer treatments
PERSONALIZED CANCER CARE
Consult for Personalized Cancer Treatment
If diagnosed with ovarian cancer:
Discuss:
- Genetic testing
- Targeted therapy options
- Long-term treatment planning
Frequently Asked Questions
Treatment that specifically attacks cancer cells based on their biology.
A drug that blocks cancer cells from repairing DNA damage.
It helps selected patients, especially in advanced or recurrent disease.
No. They are used based on specific indications and test results.
Ovarian cancer surgery is performed at Apollo Hospital, Bhat, Gandhinagar, with targeted and maintenance therapy given alongside by the medical oncology team. Consultations are at the Gota clinic in Ahmedabad.
Yes. Bring the histopathology report, the BRCA or HRD result if one has been done, the CA-125 trend and the chemotherapy record, and a second opinion can be given on whether maintenance treatment is appropriate.
Commonly two years after first-line chemotherapy, and longer in some settings, provided the disease stays controlled and the tablets are tolerated.
A BRCA mutation found in the tumour may be inherited. Germline testing clarifies that, and first-degree relatives can then be offered testing and screening through a genetic counselling service.
No. Removing all visible disease remains central to treatment. Targeted therapy is maintenance that follows chemotherapy, and it works better when surgery has already cleared the visible disease.
Dr Swati Shah, MS, DNB โ Robotic UroGynec Oncosurgeon, เช
เชฎเชฆเชพเชตเชพเชฆเชฎเชพเช เชเชตเซเชฐเชฟเชฏเชจ เชเซเชจเซเชธเชฐเชจเซ เชธเชฐเซเชเชฐเซ เชเชฐเซ เชเซ เช
เชจเซ เชเชพเชฐเซเชเซเชเซเชก เชฅเซเชฐเชพเชชเซ เชจเชเซเชเซ เชเชฐเชคเซเช BRCA เชคเชฅเชพ HRD เชเซเชธเซเชเชฟเชเช เชเชฐเชพเชตเซ เชเซ. เชเชชเชฐเซเชถเชจ Apollo Hospital, Bhat, Gandhinagar เชเชพเชคเซ เชฅเชพเชฏ เชเซ.
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